for Enterprises looking for true disaster Recovery and avoid single point of failure, AlwaysOn can be setup using SQL Cluster Instance with a stand alone SQL server Instance.meaning the primary replica is hosted on a SQL Cluster instance and Secondary replica is hosted on SQL Instance Standalone. the reason for that is to avoid the single point of failure such as the SAN
As I mentioned earlier , before DPM rollup Update 2 for System center , DPM didn’t support Protecting AlwaysOn with Cluster Setup.
First step: Install DPM Client to your WFC nodes , make sure to patch your DPM server with the latest RU2
Second Step: Create a Protection Group to protect databases on Clustered AlwaysOn .